アクティブボード・２０１７年９月
　　　　　・・・・・２０１７年　８月３１日更新・・・・・
研究発表を行った学会；
　　　Gene regulation & Expression Symposium　
　　　2015年11月 6日（Dundee, UK）
タイトル；Visualizing the error correction process that ensures sister kinetochore bi-orientation.
発表者；喜多村　悦至　氏
　　　（熊本大学　発生医学研究所　染色体制御分野）
要旨；
The proper segregation of sister chromatids to opposite poles of the cell during mitosis is essential for cell proliferation. The segregation of sister chromatids during mitosis mainly depends on the forces generated by microtubules (MTs) that attach to kinetochores (KTs). For proper chromosome segregation, KTs must capture spindle MTs and properly align on the mitotic spindle before anaphase onset. Cells undergo these processes in a step-wise manner. All these steps are crucial to ensure high-fidelity chromosome segregation in the subsequent anaphase. A major event in mitosis is equal segregation of chromosomes to two daughter cells. In this process, KT-MT interactions are of central importance as they generate major forces required for chromosome segregation. However, many aspects of KT-MT interactions, especially the steps from the initial KT-MT encounter towards establishment of sister KT bi-orientation, are still poorly understood, because the mitotic spindle consists of a large number of MTs, and individual KT-MT interactions cannot be resolved with light microscopy in live-cell imaging. To overcome this conundrum, we will develop new assay systems.