アクティブボード・２０１６年２月
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研究発表を行った学会；
・第38回日本分子生物学会年会
　２０１５年１２月１日〜４日（神戸市）
タイトル；Tsukushi expression is dependent on Notch signaling and oscillated in the presomitic mesoderm during chick somitogenesis
発表者；Uzzal Kumar Acharjee　氏
　　　（熊本大学　生命科学研究部　神経分化学分野）
要旨；
　During somitogenesis, segmentation of the body axis occurs by epithelial somites budding off from the rostral end of the unsegmented presomitic mesoderm (PSM), and its molecular regulation is achieved by a molecular oscillator and signaling molecules. Tsukushi (TSK) is a unique secreted protein and involved in diverse biological cascades in vertebrate embryos by modulating several signaling pathways at the extracellular region. However, the involvement of TSK in somitogenesis remains unknown. In this study, we investigated the detailed expression patterns of TSK at different developmental stages of a chick embryo. Chick-TSK (C-TSK) is expressed in the PSM and shows an oscillation pattern with three phases. The oscillation pattern of C-TSK in the PSM is similar to that of c-Notch1 and c-hairy1, but not to c-Delta1. Our in vitro data showed that Notch signaling is necessary for the normal expression of C-TSK and that expression of C-TSK is an intrinsic property of the anterior PSM. Our data suggest that TSK plays a role in chick somitogenesis.