アクティブボード・２０１５年　８月
　　　　　・・・・・２０１５年　８月　４日更新・・・・・
研究発表を行った学会；
・第79回日本循環器学会学術集会
　２０１５年４月２４日〜２６日（大阪）
タイトル；Interactive effects of aldehyde dehydrogenase 2*2 allele and current-smoking on the risk of myocardial infarction and hypertriglyceridemia.
発表者；守田　和憲　氏
　　　（熊本大学　大学院生命科学研究部　薬物治療学分野）
Abstract；
Background: Aldehyde dehydrogenase 2 (ALDH2) detoxifies toxic aldehydes, e.g. acetaldehyde in cigarette smoke, and the inactive ALDH*2 allele was identified to be a risk factor for coronary artery disease (CAD) in East Asians by a meta-analysis of genome-wide association studies. However, the interactive effects between the ALDH2 genotype and smoking status on CAD have not been reported.
Methods: We investigated the effects of the ALDH2 genotype and smoking status and assessed their interactive and combined effects on the risk of myocardial infarction (MI) or stable angina (SA), including 221 MI and 175 SA subjects and 473 age- and sex-matched controls without CAD. The polymorphism of ALDH2*2 was detected by a real-time Taqman allelic discrimination assay.
Results: The ALDH2*2 allele and current-smoking additively increased the risk of MI (adjusted odds ratio 4.54, 95% confidence interval 2.25-9.15), although this combination was not associated with the risk of SA. Additionally, a synergistic effect of this combination on the triglycerides levels was noted in the MI subjects, with the mean levels of triglycerides in current-smoking ALDH2*2 allele carriers and non-carriers being 1.8 ± 1.0 mmol/L vs. 1.2 ± 0.4 mmol/L, P < 0.01 respectively.
Conclusions: These preliminary findings suggest that the combination of the inactive ALDH2*2 allele and current-smoking may be a novel risk factor for MI.