アクティブボード・２０１４年　７月
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研究発表を行った学会；
・第４７回日本発生生物学会年会
　２０１４年５月２７日〜３０日（名古屋）
タイトル；Human Fibroblast Reprogramming by Lactic Acid Bacteria.
発表者；伊藤　尚文　氏
　　　（熊本大学　大学院生命科学研究部　神経分化学分野）
Abstract；
Living organisms have been classified on the basis of cell structure into three groups: eubacteria, archaea, and eukaryotes. Now, it is widely believed that eubacteria infected archaea, genomic DNA was transferred to the archaea, and they evolved into eukaryotic cells.
The human gastrointestinal tract is colonized by a vast community of symbionts and commensals. Lactic acid bacteria (LAB) form a group of related, low-GC-content, gram-positive bacteria that are considered to offer a number of probiotic benefits to general health. While the role of LAB in gastrointestinal community has been the subject of extensive study, little is known about how commensal prokaryotic organisms directly influence eukaryotic cells.
Here, we demonstrate the generation of multi-potential cells from adult human dermal fibroblast cells by incorporating LAB (1). LAB-incorporated cell clusters are similar to embryoid bodies derived from embryonic stem cells and can differentiate into endodermal, mesodermal, and ectodermal cells in vivo and in vitro. LAB-incorporated cell clusters express a set of genes associated with multipotency, and microarray analysis indicates a remarkable increase of NANOG, a multipotency marker, and a notable decrease in HOX gene expression in LAB-incorporated cells. During the cell culture, the LAB-incorporated cell clusters start to express early senescence markers without cell death. Thus, LAB-incorporated cell clusters have potentially wide-ranging implications for cell generation, reprogramming, and cell-based therapy.