アクティブボード・２０１０年７月
　　　　　・・・・・２０１０年　７月　２日更新・・・・・

研究発表を行った学会；
・CDB Symposium 2010. "Frontiers in Organogenesis"
　２０１０年　３月２３日〜２５日（神戸）

タイトル；Kif-k regulates the Mesenchymal Condensation on Contact with Ureteric Buds in Kidney Development.
　
発表者；　阪口　雅司　氏
　　　（熊本大学　発生医学研究所　腎臓発生分野）

Abstract；
The kidney develops through reciprocal interactions between two precursor tissues: the metanephric mesenchyme and the ureteric bud. We previously demonstrated that the zinc finger protein Sall1 is essential for ureteric bud attraction toward the mesenchyme. Here we show that Kif-ｋ, a kinesin family gene, is a downstream target of Sall1 and that disruption of this gene causes kidney agenesis because of impaired ureteric bud attraction. In the Kif-ｋ-null metanephros, compact adhesion between mesenchymal cells adjacent to the ureteric buds and the polarized distribution of integrin α8 were impaired, resulting in failed maintenance of Gdnf, a critical ureteric bud attractant. Overexpression of Kif-k in vitro caused increased cell adhesion through interactions with non-muscle myosin. Thus Kif-k is essential for kidney development because it regulates the adhesion of mesenchymal cells in contact with ureteric buds.