アクティブボード・２００９年１０月
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研究発表を行った学会；
・16th International Society for Developmental Biology Congress
Molecular Basis and Therapeutic Potentials".
　２００９年９月６日〜１０日（Edinburgh International Conference Centre, Scotland, UK.）

タイトル；『Analysis of morphological phenotypes in Tsukushi (TSK) KO mice brain.』

　
発表者；　伊藤　綾子　氏
　　　（熊本大学　大学院医学薬学研究部　神経分化学分野）

Abstract；
Recently, We found that TSK inhibited Wnt2b activity in vitro and in ovo by interacting with Wnt2b receptor at the CMZ. I analyzed TSK expression pattern in the mouse brain and found the morphological abnormality in TSK-KO mouse brain. TSK was strongly expressed in the Sub-Ventricular Zone (SVZ) and Dentate Gyrus (DG) in the hippocampus, where the neural stem cells exist. I observed the enlargement of lateral ventricle (LV) in the adult TSK-KO mouse comparing with wild type mouse. Now, I’m investigating whether TSK is involved in the regulation of the neural stem cell proliferation as a niche molecule in the adult mouse brain.